Research archive
Human cell model research
The latest research on new approach methodologies (NAMs), organoids, assembloids, human iPSCs, stem cells and enabling biotechnology. Reviewed and ready.
Two neural ectoderm lineages redraw the brain's earliest map
Mouse lineage tracing and human pluripotent stem-cell differentiation support parallel anterior and posterior neural ectoderm progenitors with distinct regional fates.
HCMX EditorialHuman cortical organoids fill a missing cortical niche in mice
Kaganovsky, Kelley, Gschwind and colleagues combine a cortex-depleted mouse host with human cortical organoid grafts to create a distributed, active xenocortical system.
HCMX EditorialA human motor circuit assembled across three tissues
Andersen et al. connect cortical, hindbrain/spinal and skeletal-muscle spheroids into a human circuit that converts cortical stimulation into muscle contraction.
HCMX EditorialA synchronized clock for human neuronal maturation
Ciceri et al. combine synchronized cortical neurogenesis, a multimodal maturation atlas and timed epigenetic perturbation to expose—and partially release—the intrinsic brake on human neuronal maturation.
HCMX Editorial